First international comparison of fountain primary frequency standards via a long distance optical fiber link

International audienceWe report on the first comparison of distant caesium fountain primary frequency standards (PFSs) via an optical fiber link. The 1415 km long optical link connects two PFSs at LNE-SYRTE (Laboratoire National de métrologie et d'Essais-SYstème de Références Temps-Espace) in Paris (France) with two at PTB (Physikalisch-Technische Bundesanstalt) in Braunschweig (Germany). For a long time, these PFSs have been major contributors to accuracy of the International Atomic Time (TAI), with stated accuracies of around 3 × 10 −16. They have also been the references for a number of absolute measurements of clock transition frequencies in various optical frequency standards in view of a future redefinition of the second. The phase coherent optical frequency transfer via a stabilized telecom fiber link enables far better resolution than any other means of frequency transfer based on satellite links. The agreement for each pair of distant fountains compared is well within the combined uncertainty of a few 10 −16 for all the comparisons, which fully supports the stated PFSs' uncertainties. The comparison also includes a rubidium fountain frequency standard participating in the steering of TAI and enables a new absolute determination of the 87 Rb ground state hyperfine transition frequency with an uncertainty of 3.1 × 10 −16. This paper is dedicated to the memory of André Clairon, who passed away on the 24 th of December 2015, for his pioneering and long-lasting efforts in atomic fountains. He also pioneered optical links from as early as 1997

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]

Integrative model of the response of yeast to osmotic shock

Integration of experimental studies with mathematical modeling allows insight into systems properties, prediction of perturbation effects and generation of hypotheses for further research. We present a comprehensive mathematical description of the cellular response of yeast to hyperosmotic shock. The model integrates a biochemical reaction network comprising receptor stimulation, mitogen-activated protein kinase cascade dynamics, activation of gene expression and adaptation of cellular metabolism with a thermodynamic description of volume regulation and osmotic pressure. Simulations agree well with experimental results obtained under different stress conditions or with specific mutants. The model is predictive since it suggests previously unrecognized features of the system with respect to osmolyte accumulation and feedback control, as confirmed with experiments. The mathematical description presented is a valuable tool for future studies on osmoregulation in yeast and—with appropriate modifications—other organisms. It also serves as a starting point for a comprehensive description of cellular signaling

Optical fiber link for ultra-stable frequency dissemination and atomic clock comparisons

International audienceThe transfer of ultra-stable frequencies between distant laboratories is required by many applications from fundamental metrology to high-precision measurements. For that purpose, optical fibre links have been intensively studied over the last decade. They have demonstrated impressive results far beyond the GPS capabilities on distances up to 2000 km, thanks to an active compensation of the fiber propagation noise.Up to now, optical links has been mainly implemented between two labs, when future applications will require the development of metrological fiber networks. Towards this goal, we have developed a few techniques which allow us to distribute the ultrastable optical signal to many users simultaneously. We have designed repeater laser stations, which can be used to build a cascaded link or to distribute the ultrastable signal among two optical links [1]. These stations allow us also to compare the output end signals of two optical links. These versatile stations will be a key-component of the national metrological network currently being developed in France within the Refimeve+ project. To complete the network, we have demonstrated the extraction of the ultrastable signal from a main link and its seeding to a secondary link [2].Optical links are already been successfully used for clocks comparison. Recently we were able to compare the atomic clocks of the French and German National Metrology Institutes through two connected optical links of total length 1415-km [3]. We found that the two fully independent Sr lattice optical clocks at the two sites agreed to better than 5x10-17 limited only by the clocks uncertainties. A fractional statistical uncertainty of 3x10-17 was reached after only 1000 s averaging time, which is 10 times better, and more than four orders of magnitude faster than with any other existing frequency transfer method. The atomic fountain primary frequency standards from the two institutes were also compared and they were found to agree well within their combined uncertainties of a few 10-16 [4]